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PhD position in molecular biology available starting September 2009 (Munich, Germany) PDF Print E-mail
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Saturday, 24 April 2010 20:46

A PhD student position starting September 2009 is available in the laboratory of Dr. Antonio Sarikas at the Institute of Pharmacology and Toxicology, Technische Universität München (TUM), Germany.

Research in our lab focuses on the role of the ubiquitin-proteasome system in growth control and disease mechanisms.

Project description:

The Cullin7 E3 ubiquitin ligase plays an important role in growth control and oncogenic transformation by the SV40 tumor virus (1, 2). We identified insulin receptor substrate-1 (IRS-1), a critical mediator of insulin and insulin-like growth factor 1 (IGF-1) signaling, as a proteolytic target of the Cullin7 E3 ligase (3).

The aim of this project is to study the role of Cullin7 mediated degradation of IRS-1 in growth control and cellular transformation by SV40.

The project will cover a broad range of state-of-the-art methods of molecular cell biology and protein biochemistry. Salary and 3 year contract according to TVöD.

Requirements and Application:

The ideal candidate has a diploma / master degree in biology, biochemistry or a closely related field and a strong background in molecular biology and/or protein biochemistry.

To apply, please submit your CV, a brief description of your research experience, and the addresses of two referees PER EMAIL ONLY to:

Dr. Antonio Sarikas, Institut für Pharmakologie und Toxikologie, Biedersteiner Str. 29, 80802 Munich, Germany;
Email: This e-mail address is being protected from spambots. You need JavaScript enabled to view it

Literature: 1. Huber, C. / Dias-Santagata, D. et al. (2005). Identification of mutations in CUL7 in 3-M syndrome. Nat Genet. 37: 1119-24. 2. Sarikas, A. et al. (2008). The cullin7 E3 ubiquitin ligase: a novel player in growth control. Cell Cycle 7: 3154-3161. 3. Xu, X. / Sarikas, A. et al. (2008). The CUL7 E3 ubiquitin ligase targets insulin receptor substrate 1 for ubiquitin-dependent degradation. Mol Cell 30: 403-414;



Dr. Antonio Sarikas
This e-mail address is being protected from spambots. You need JavaScript enabled to view it
Institute for Pharmacology and Toxicology, Technische Universität München (TUM)
Munich, Germany

Ansprechpartner: Dr. Antonio Sarikas



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