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PhD student (Heidelberg, Neckar) PDF Print E-mail
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Saturday, 24 April 2010 20:46

The Developmental Biology Junior Group at the BIOQUANT Center in Heidelberg is looking for a

PhD student.

You will join the research group of Dr. Ingrid Lohmann at the University of Heidelberg, Germany. One of the interests of the group is to understand the diversification of the nervous system in Drosophila. In Drosophila, neurons are arranged in stereotyped patterns with remarkable differences between segments, which makes the fruit fly an attractive model to examine the mechanisms of nervous system diversification. Hox proteins represent one important class of transcriptional regulators involved in the diversification of neurons along the anterior-posterior (A/P). Despite this fact, it is still largely unknown how Hox proteins execute their neuronal functions on a cellular and molecular level. The group of Ingrid Lohmann has identified a large number of neuronal Hox downstream genes by gene expression profiling experiments and used computational tools to identify Hox response elements (HREs) with neuron specific functions. By combining data from both experimental approaches, !
complete Hox-dependent regulatory network underlying neuronal diversification can be reconstructed. In addition, the identified HREs are essential tools to understand how the axial information provided by Hox proteins is integrated with other patterning signals by cis-regulatory elements, which are responsible for cell-type specific expression of Hox target genes.

The successful applicant will analyze selected neuronal Hox downstream genes using molecular, genetic, cellular and genomic techniques, and will generate and characterize transgenic Drosophila lines. Experience in Drosophila breeding and genetics, knowledge of molecular and immunological techniques are required. The successful applicant should also be experienced in bright-field and confocal microscopy. The ability to quickly integrate into an interdisciplinary team and to work independently within an academic research environment is essential. The position is available in october 2009, the salary is according to TV-L regulations. Disabled persons with comparable skills will be preferentially considered. Applications should be sent till 30.08.2009 to:

Dr. Ingrid Lohmann
BQ 0032 NWG Developmental Biology
Im Neuenheimer Feld 267
69120 Heidelberg

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Brigitta Martin
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Heidelberg, Neckar

Ansprechpartner: Dr. Ingrid Lohmann, This e-mail address is being protected from spambots. You need JavaScript enabled to view it



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