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PhD student in developmental gene regulation (Nijmegen, The Netherlands) PDF Print E-mail
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Saturday, 24 April 2010 20:46

The department of Molecular Biology has an opening for a PhD student to conduct scientific research on the regulation of gene expression during vertebrate embryonic development. One of the most profound questions in molecular and developmental biology is how gene expression patterns in the embryo emerge from a common set of factors derived from the fertilized egg. One of the key requirements for regulated gene expression is the gene-selective initiation of transcription at the promoter, the understanding of which is important for cancer, normal development and disease. Some mechanisms of transcription initiation have been identified and characterized, however the full complement of in vivo mechanisms is not known. Moreover, the biological function of mechanistic diversity of transcriptional regulation in development is not well understood. In this project the role of TBP family members (TBP, TBP2, TLF), TFIID and TFTC/SAGA subunits, selective RNA polymerase II pausing and ch!
romatin structure will be investigated in the context of developmental gene expression, dorsal-ventral patterning and gastrulation. This will uncover how generic transcription (co)factors selectively contribute to specialized developmental programs.

Requirements: You are a biologist or biochemist with a high level of molecular interest in gene regulation and embryonic development. An MSc degree in Molecular Life Sciences, Biology or related discipline and molecular research experience are required. A background in the field of transcriptional regulation, bioinformatics skills (to analyze large data sets), and experience with embryological techniques are preferred but not required.

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Von:

Gert Jan C. Veenstra
g.veenstra AT ncmls.ru.nl
Nijmegen Centre for Molecular Life Sciences
Nijmegen, The Netherlands

Ansprechpartner: g.veenstra AT ncmls.ru.nl

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