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Doktorandenstelle/Phd position in Cytoskeletal signaling and cancer cell motility (Heidelberg, Germany) PDF Print E-mail
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Saturday, 24 April 2010 20:46

Applications are welcome for a motivated PhD student to join our research team to study actin nucleation mechanisms in cancer cell invasion. We are particularly interested in the regulations of the large protein family of the Diaphanous formins and their impact on cytoskeletal dynamics for cell morphology, polarity and motility. A focus of the lab is to unravel the molecular functions of RhoGTPase-regulated formins and the tight interplay, between cytoskeleton-controlled transcription and cancer cell progression and metastasis thereby identifying novel molecular targets for invasive and inflammatory diseases. Interested applicants should send a CV (max 2 pages) along with the contact details of two references and an outline (max 1 page) why they are interested in our research to This e-mail address is being protected from spambots. You need JavaScript enabled to view it .
Further information can be found at http://www.cellnetworks.uni-hd.de/pub/start_start_for.php
or http://www.medizinische-fakultaet-hd.uni-heidelberg.de/index.php?id=107594&L=en

References:
Faix J. and Grosse R. 2006. Staying in shape with formins. Dev. Cell 10: 693-706.
Brandt D.T., Marion, S., Griffiths G., Watanabe T., Kaibuchi K. and Grosse R. 2007. Dia1 and IQGAP1 interact in cell migration and phagocytic cup formation. J. Cell Biol. 177, 193-200.
Kitzing T.M., Sahadevan A, Brandt, D.T., Knieling H., Hannemann S., Fackler O.T., Großhans J. and Grosse R. 2007. Positive feedback between Dia1, LARG and RhoA regulates cell morphology and invasion. Genes Dev. 21:1478-1483.
Brandt DT, Baarlink C, Kitzing TM, Kremmer E, Ivaska J, Nollau P, Grosse R. 2009. SCAI acts as a suppressor of cancer cell invasion through the transcriptional control of beta1-integrin. Nat Cell Biol. 11(5):557-568.


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Von:

PD Dr Robert Grosse
This e-mail address is being protected from spambots. You need JavaScript enabled to view it
University of Heidelberg
Heidelberg, Germany

Ansprechpartner: R Grosse, This e-mail address is being protected from spambots. You need JavaScript enabled to view it

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