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PhD position - Improving protein stability using concepts from rigidity theory (Düsseldorf) PDF Print E-mail
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Saturday, 24 April 2010 20:46

Applications are invited for a PhD student position immediately available in the Computational Pharmaceutical Chemistry and Molecular Bioinformatics group in the Department of Natural Sciences and Mathematics at the University of Duesseldorf.

The project aims at developing a computational strategy to improve protein stability at high temperatures based on an understanding of the relationship between microscopic structure and macroscopic stability/structural rigidity. The structural rigidity shall be probed by constraint network analysis recently introduced by us (Radestock, Gohlke, Eng. Life Sci. 2008, 8, 507), which allows for identifying structural features from which a destabilization of the structure originates upon thermal unfolding. This information can be exploited in data-driven protein engineering by pointing to residues that should be varied to obtain a protein with higher thermostability. The project will be performed in collaboration with an industrial partner.

Ideal candidates would have a strong background in bioinformatics, biophysics, computational or theoretical chemistry, biochemistry, structural biology or related disciplines. Experience/interest in molecular modeling and simulation of biological systems, advanced programming skills (C, Perl, Python), familiarity with the UNIX/Linux operating system, and an interest in developing new methodologies are highly desirable.

Applicants should submit applications (a current CV, description of scientific experience and interests, and contact data of three references) by email to Prof. Dr. Holger Gohlke, This e-mail address is being protected from spambots. You need JavaScript enabled to view it (Webpage: http://cpclab.uni-duesseldorf.de)


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Von:

Prof. Dr. Holger Gohlke
This e-mail address is being protected from spambots. You need JavaScript enabled to view it
Heinrich-Heine-University
Düsseldorf

Ansprechpartner: Prof. Dr. Holger Gohlke, This e-mail address is being protected from spambots. You need JavaScript enabled to view it

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*http://jobs.uni-hd.de
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