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PhD Student Position in Cancer Biology / Neurooncology (Giesen) PDF Print E-mail
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Saturday, 24 April 2010 20:46

The Institute of Neuropathology at the Justus Liebig University in Giessen, Germany, Director Prof. Till Acker, is inviting applications for a

PhD Student Position

in the field of cancer biology / neurooncology. The position is available immediately.

We are looking for enthusiastic and highly motivated biology, biochemistry or pharmacy students holding, or about to obtain, an MSc degree, diploma or equivalent, with a strong interest in cancer biology and a background in molecular or cell biology.

Project description:
Our group has a long-standing interest in the role of microenvironmental factors, particularly hypoxia, in the regulation of tumor progression. We have dissected the differential functions of the key transcriptional regulators hypoxia inducible factor (HIF)-1alpha and HIF-2alpha in tumor growth and we are actively investigating the involvement of HIF regulators and downstream targets in tumorigenesis. At the same time, a growing body of evidence indicates that tumor development is critically dependent on the function of a small subset of cells which possess stem cell properties and are termed tumor stem cells (TSCs). Our own recent work has identified a detailed transcriptional signature of TSCs, helping to delineate specific TSC markers that are functionally involved in TSC maintenance and have prognostic value for glioblastomas. Furthermore, we have also been able to uncover discrete niches in which the TSCs reside within glioblastomas. The proposed projects will focus on !
the identification and characterization of key transcriptional factors and signaling pathways that regulate the interplay between TSCs and the niche.

Training and methods:
We offer an open, supportive, internationally competitive academic environment with excellent training opportunities within the PhD graduate program of the International Giessen Graduate school for Life Sciences (GGL: http://www.uni-giessen.de/cms/fbz/zentren/ggl; and http://ggl-uni-giessen.de/project). We have won a number of external research grants and are involved in several national and international collaborative projects.
We use a wide spectrum of methods: cloning, cell culture, biochemistry, quantitative RT-PCR, FACS, ELISA, cell-based assays (proliferation, apoptosis, migration, 3D invasion etc.), virally-based gene delivery and RNAi silencing, immunohistochemistry, in situ hybridization, light, epifluorescence and confocal microscopy, image analysis, animal models and in vivo transplantation.

Please send your applications, including a CV, certificates and references by email or post to: Dr. Boyan Garvalov, Email: Boyan.Garvalov (at) patho.med.uni-giessen.de; Institut für Neuropathologie, 3. OG, Aulweg 123, 35392 Giessen, Germany.

Selected references:
Cancer Research 2009, in press
Lancet Oncology 2006; 7(6):521-3
Cardiovascular Research 2006; 71(2):195-207
Cancer Cell 2005; 8(2):131-41
Nature Medicine 2002; 8(7):702-10

Website: http://www.uniklinikum-giessen.de/neuropatho/forschung/forschung.html



Boyan Garvalov
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Institute of Neuropathology, Justus Liebig University

Ansprechpartner: Boyan Garvalov



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