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PhD in Biophysics/Biochemistry (University of Bayreuth, Germany) (Bayreuth, Germany) PDF Print E-mail
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Thursday, 14 October 2010 00:04

Fluorescence Spectroscopy Investigation of the Enzymatic Mechanism of Phytochelatin
Synthase, an Enzyme Able to Cleave and Form Peptide Bonds

This DFG-funded project aims to elucidate the molecular mechanism of Phytochelatin
synthase (PCS) by characterizing the energetics and the kinetics of its catalytic cycle. For
this purpose, we will employ fluorescently-labeled and chemically-modified GSH analogues.
By combining experimental (Fluorescence, UV-Vis and NMR spectroscopy) with theoretical
(molecular dynamics, electrostatics, quantum chemistry) techniques, we will investigate the
function of PCS and connect the structural information with physiological data.

Stimulating collaborations at the University of Bayreuth with Prof. Stephan Clemens (Plant
Physiology), \ Prof. Rainer Schobert (Organic Chemistry) and Prof. Matthias Ullmann
(Theoretical Biophysics) will enrich the scientific environment and favor the fulfillment of the
project.

The candidate should have a good background in Biophysics and/or Biochemistry. A CV with
study records and the name of one academic willing to send a recommendation letter are
requested.

For further information please contact:

Dr. Elisa Bombarda
e-mail: This e-mail address is being protected from spambots. You need JavaScript enabled to view it
tel. +49 (0)921 / 55 43 64
http://www.bisb.uni-bayreuth.de/bombarda

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Von:

Dr. Elisa Bombarda
This e-mail address is being protected from spambots. You need JavaScript enabled to view it
University of Bayreuth, Germany
Bayreuth, Germany

Ansprechpartner: This e-mail address is being protected from spambots. You need JavaScript enabled to view it

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