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Thursday, 14 October 2010 00:04

Open PhD position in life sciences (TV-L E13/50%) available in the Division of Experimental Neurosurgery, Neuroscience Center starting from October 1st 2010. The position is funded for three years.

The position is within a BMBF joint project entitled “Impact of Curcumin with advanced bioavailability on STAT3 signaling in mouse brain tumors”

The PhD project deals with the anti-cancer efficacy of the non-toxic spice compound Curcumin on glioblastomas, the most common and deadly human brain tumor by studying its mechanistic influence on key signaling pathways, e.g. JAK/STAT3. In particular, the effects of new formulations of Curcumin on STAT3 phosphorylation, STAT3 DNA binding activity, expression of STAT3 target genes, proliferation, migration, invasion, apoptosis resistance etc. will be scrutinized using in vitro (MTT, scratch, transwell and caspase assay, TaqMan, WB, histology, IHC, IF microscopy, transfection, transduction, site-directed mutagenesis etc.) and in vivo (i.c. transplantation, i.p. injection etc.) glioma models.

Applicants should bring an excellent master (or equivalent) in biology, or other life sciences and a thorough training in molecular and cellular biological techniques. Readiness for performing animal experiments is a prerequisite. Applications (curriculum vitae, a summary of research experience, and contact details for two references) should be directed to Dr. Jakob Weissenberger, Goethe-Universitätsklinikum, Neuroscience Center, Experimentelle Neurochirurgie, Heinrich-Hoffmann-Str. 7, D-60528 Frankfurt am Main, E-mail: This e-mail address is being protected from spambots. You need JavaScript enabled to view it within the next three weeks. Note that documents will not be returned and destroyed after a retention period of five month.

The University strives to increase the number of women among the faculty staff and therefore explicitly encourages the application of female scientists. Disabled persons with corresponding aptitude for the position will be favored.


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Von:

Dr. Jakob Weissenberger
This e-mail address is being protected from spambots. You need JavaScript enabled to view it
Goethe-Universitätsklinikum, Neuroscience Center, Experimentelle Neurochirurgie
Frankfurt am Main

Ansprechpartner: Dr. Jakob Weissenberger, This e-mail address is being protected from spambots. You need JavaScript enabled to view it

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