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PhD Student Position to Investigate the Epigenetics of Tumor Formation in a Conditional Knockout Mouse Model PDF Print E-mail
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Thursday, 14 October 2010 00:04

Fachgebiete: Biologie
Thema: Doktorarbeit / Diplomarbeit: PhD Student Position to Investigate the Epigenetics of Tumor Formation in a Conditional Knockout Mouse Model
Ansprechpartner: Prof. Steven Johnsen
Antwort an: This e-mail address is being protected from spambots. You need JavaScript enabled to view it
Institution: Göttingen Center for Molecular Oncology
Ort: 37077 Göttingen, Justus-von-Liebig-Weg 11

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Are you looking for an opportunity to perform your doctoral thesis work in a young, dynamic and successful environment with excellent conditions and close interaction with your advisor?

Our group is growing and are searching for a highly talented and motivated individual to join the group of Prof. Dr. Steven A. Johnsen in the Department of Molecular Oncology at the Göttingen Center for Molecular Biosciences.

The proposed dissertation project (Ph.D. or Dr. rer. nat.) will utilize a new conditional knockout mouse model developed in our laboratory to investigate the effects of the loss of specific chromatin modifying enzymes during mammary tumorigenesis. The project will be complemented by cell culture analyses in which the regulation of transcriptional initiation, elongation, signal transduction pathways, DNA damage response, histone modifications, ubiquitination and cell cycle progression. We make use of such modern molecular and cellular biological techniques as quantitative real-time PCR, chromatin immunoprecipitation (ChIP), cell culture, siRNA knockdown, reporter gene assays, confocal immunocytochemistry, etc. This work is a continuation of our ongoing work related to the role of covalent histone modifications in controlling nuclear processes (e.g., transcription, mRNA processing, etc.) during tumorigenesis and metastasis of cancer (see Shema, et al., 2008, Genes Dev. 22:2664;
Johnsen, et al., 2009, Cancer Res. 69:128; and Pirngruber, et al., EMBO reports 10:894). Our goal is to gain a better understanding of the molecular defects during tumor progression in order to develop new strategies to combat cancer. For more information about our work please visit our website at http://www.moloncol.med.uni-goettingen.de/content/researchgroups/25.htm.


The following qualifications are expected:
• Excellent grades during the qualifying degree (Diplom or M.Sc.) in biology or a closely related field.
• Applicants will be expected to meet the admission requirements of the Göttingen Graduate School for Neurobiology and Molecular Biosciences (see http://www.uni-goettingen.de/en/sh/56870.html).
• Experience in basic research in molecular and cellular biology (i.e., cell culture, transfection, plasmid construction, PCR, Western blot, immunofluorescence studies)
• You should be ambitious, creative, goal-oriented, able to work well in a team and pay close attention to detail.
• Excellent English skills (since we have a highly international team).

In return you can expect:
• Close supervision on a very interesting and disease-relevant project.
• A young and dynamic work environment.
• A good team atmosphere, excellent access to the advisor, the ability to contribute your own ideas and the chance to publish in excellent international journals.

A complete application should be sent by email only as a single PDF file to This e-mail address is being protected from spambots. You need JavaScript enabled to view it and should include a curriculum vitae, university transcripts and certificates. 2-3 letters of recommendation should be sent directly via email from the Diplom/M.Sc. supervisor and others who can judge the applicant’s scientific potential.

Prof. Dr. Steven A. Johnsen
Department of Molecular Oncology
Göttingen Center for Molecular Oncology
Georg-August-Universität Göttingen

http://www.moloncol.med.uni-goettingen.de/content/researchgroups/25.htm

Anfangsdatum: 1. Oktober 2010

geschätzte Dauer: 3.5 years

Bezahlung: TV-L E13/2 (formerly BAT IIa/2)

Homepage: http://www.moloncol.med.uni-goettingen.de/content/researchgroups/25.htm

*http://jobs.uni-hd.de
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